Dermal spray apparatus with disposable cartrdige and method

ABSTRACT

A system and method for dermal spraying includes a portable, hand - held dermal application device with one or more disposable cartridges that spray a dermal formulation onto the skin, the disposable cartridge having a nozzle that can be activated by placing the cartridge into the spray device.

FIELD OF THE INVENTION

This application relates to dermal spray devices that utilize disposablecartridges, the disposable cartridges containing fluid that is dispensedby the spray devices.

BACKGROUND OF THE INVENTION

Skin care is very important. Many are turning to plant based and naturalremedies. Certain plant-derived constituents can protect skin fromdeleterious effects, carcinogens, and a variety of chemicalinteractions. This concept has much scientific backing.

Human skin includes the epidermis, dermis and subcutis. The epidermisincludes the stratum corneum and an underlying pigment layer. Thestratum corneum is the outer layer of skin that protects the body. It iscomposed primarily of layers of dead, flattened keratinocytes surroundedby a phospholipid matrix. This acts in a similar as brick and mortarwall and functions to provide barrier to a microbial parasites as wellas environmental toxins. The stratum corneum also presents a significantbarrier to the delivery of transdermal drugs, vitamins, minerals,nutraceuticals and cosmeceuticals.

There are two major transdermal pathways. One is the intercellularroute, which includes the movement of topically applied products aroundthe cells of the stratum corneum via a phospholipid matrix thatsurrounds the cells. This is a tortuous path, so there are challenges tooptimizing the speed of delivery and efficacy of skin-improvingsubstances.

The other pathway is the transcellular pathway, which includesskin-improving substances directly passing through the cytoplasm of thedead keratinocytes of the stratum corneum, as well as the phospholipidsmatrix surrounding the cells. This is a more direct pathway yet thereare still many challenges.

In either case, spraying a formulated fluid at a controlled pressure,spray pattern, and flow rate way can enhance penetration through thestratum corneum, so that the beneficial substances in the formulatedfluid can penetrate and nourish the dermis, and in some cases enter thevasculature directly through the skin.

In the case of cosmetics and medical skincare products, the spraypattern, flow rate and other delivery aspects can be adjusted tooptimize delivery to a desired region of the skin. For example, certaincosmetics can be delivered to provide a uniform coating on top of thestratum corneum, certain pigmentation products may be designed to reachthe pigment layer under the stratum corneum.

U.S. Pat. No. 10,252,283 to Gouchtchina and Gallar includes a dermalspray apparatus that allows a system and method for dermal sprayingincludes a portable, hand-held skin care device with disposableformulation capsules that spray a formulation onto the skin. The deviceis set to maximize absorption and provide professional and uniformquality of application. The device receives, clamps and identifies theformulation capsules and its contents. Control circuitry regulates theformulation delivery. This assures the quantity, proportion, speed andtiming of the application of the cosmetic formulation, includingself-cleaning cycle operation and single button control logic. Thecapsule enables convenience and sterility from use of disposablecapsules at home. Preferably the capsules contain a cosmeticformulation.

There remains a need to improve cartridge systems for use in dermalspray devices and system.

SUMMARY OF THE INVENTION

In one aspect, the invention involves a cartridge for dispensing aliquid comprising: a nozzle assembly, a liquid reservoir, and a capattached to the liquid reservoir, wherein the cap is adapted to engagethe nozzle assembly; the nozzle assembly comprising an inner body and anouter body, the inner body and outer body forming a first fluid passagetherebetween, the first fluid passage adapted to deliver compressed air,the inner body comprising a second fluid passage in its interior, thesecond fluid passage adapted to deliver liquid from the liquidreservoir; wherein the nozzle assembly is moveable in a controlleddirection relative to the cap; and the inner body of the nozzle assemblyis adapted to pierce the liquid reservoir when the nozzle assembly ismoved in the direction of the liquid reservoir to allow liquid from theliquid reservoir to flow into the second fluid passage.

The nozzle assembly of the cartridge may comprises a guide adapted totranslate lateral motion into vertical motion for engaging the nozzleassembly with the liquid reservoir. The fluid reservoir of the cartridgemay be a pouch and the cap seals the pouch. The cap may include recessesfor capturing air bubbles in the fluid of the reservoir. The nozzleassembly may further comprise at least one guide flange adapted to guidemovement of the nozzle assembly in a back and forth direction relativeto the liquid reservoir. The guide flange, if used, is designed to guidemovement of the nozzle assembly in a rotational direction relative tothe liquid reservoir in addition to a back and forth direction relativeto the liquid reservoir. The nozzle assembly may have a conical orrectangular shape, among others. In one aspect, the nozzle assembly hasa rectangular shape and the first fluid path and second fluid path exitthe nozzle assembly at about a 45 degree angle relative to thehorizontal. In another aspect, the nozzle assembly comprises a firstguide member and a second guide member, wherein the first guide memberand second guide member are adapted to engage with the cap in a mannerthat permits the nozzle assembly to move in a controlled directionrelative to the cap.

In another aspect, the invention relates to a dermal spray device fordispensing liquid from a cartridge, the dermal spray device comprising:a housing; a source of a compressed air; and a cartridge receiver,wherein the cartridge receiver is adapted to accept a cartridgeincluding both a liquid container and a spray nozzle, wherein the dermalspray device dispenses liquid from the cartridge by supplying thecompressed air to the nozzle of the cartridge, the nozzle assemblydrawing liquid from the liquid container and mixing it with thecompressed air. One or more of the features above related to thecartridge may be present in a cartridge that works with this dermalspray device.

The device may further comprise a sliding cover adapted to position thecartridge in the dermal spray device wherein the cartridge so positionedis capable of dispensing liquid through the spray nozzle. The slidingcover, if used, is adapted to engage with spray nozzle of the cartridgeand activate the spray nozzle when the sliding cover is moved into anengaged position. The dermal spray device may include a base with aninductive charging element that allows for charging of a battery of thedermal spray device. The device may further comprise a compressor forsupplying compressed air to the spray nozzle. The cartridge receiver maycomprise a fluid conduit in fluid communication with the compressor,wherein the fluid conduit is adapted to engage with the cartridge.

In another aspect, the invention relates to a method of spraying aliquid onto a user's skin using the dermal spray device comprisinginserting the cartridge including both a liquid container and a spraynozzle in the dermal spray device; and directing a spray of the liquidfrom the liquid container through the spray nozzle toward the user'sskin. The method may also include a step of closing a cover adapted toposition the cartridge in the dermal spray device wherein the cartridgeso positioned is capable of dispensing liquid through the spray nozzle.In one aspect, closing the cover may engage the spray nozzle by movingit toward the liquid container of the cartridge allowing liquid to flowinto the spray nozzle.

In another aspect the invention involves a dermal spray system fordispensing liquid from a cartridge, the dermal spray device comprising:a housing; a source of a compressed air; a cartridge receiver, whereinthe cartridge receiver is adapted to accept a cartridge; wherein thedermal spray device dispenses liquid from the cartridge by supplying thecompressed air to the nozzle of the cartridge, the nozzle drawing liquidfrom the liquid container and mixing it with the compressed air; andwherein the cartridge comprises: a nozzle assembly, a liquid reservoir,and a cap attached to the liquid reservoir, wherein the cap is adaptedto engage the nozzle assembly; the nozzle assembly comprising an innerbody and an outer body, the inner body and outer body forming a firstfluid passage therebetween, the first fluid passage adapted to delivercompressed air, the inner body comprising a second fluid passage in itsinterior, the second fluid passage adapted to deliver liquid from theliquid reservoir; wherein the nozzle assembly is moveable in acontrolled direction relative to the cap; and the inner body of thenozzle assembly is adapted to pierce the liquid reservoir when thenozzle assembly is moved in the direction of the liquid reservoir toallow liquid from the liquid reservoir to flow into the second fluidpassage.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 shows a dermal spray apparatus.

FIG. 2A shows a dermal spray cartridge according to an embodiment of theinvention.

FIG. 2B shows a first side view of a pouch-type reservoir which formspart of a cartridge according to an embodiment of the invention.

FIG. 2C shows a second side view of a pouch-type reservoir which formspart of a cartridge according to an embodiment of the invention.

FIG. 2D shows a bottom view of a pouch-type reservoir which forms partof a cartridge according to an embodiment of the invention.

FIG. 2E shows a top view of a pouch-type reservoir which forms part of acartridge according to an embodiment of the invention.

FIG. 2F shows a side view of a nozzle assembly according to an aspect ofthe invention.

FIG. 2G shows a perspective view of a nozzle assembly according to anaspect of the invention.

FIG. 3 shows a diagram of an exemplary process for making a pouch-typereservoir to be used with a cartridge according to an aspect of theinvention.

FIG. 4A shows a nozzle having a 45 degree bend according to an aspect ofthe invention.

FIG. 4B shows a dermal spray cartridge having the nozzle of FIG. 4Aaccording to an embodiment of the invention.

FIG. 4C shows a perspective view of an exemplary dermal spray deviceincorporating the nozzle of FIG. 4A.

FIG. 4D shows a perspective view of an exemplary dermal spray deviceincorporating the nozzle of FIG. 4A.

FIG. 4E shows a side view of an exemplary dermal spray deviceincorporating the nozzle of FIG. 4A with a cartridge door in an openposition.

FIG. 4F shows a perspective view of an exemplary dermal spray deviceincorporating the nozzle of FIG. 4A with a cartridge door in an openposition.

FIG. 5A shows a dermal spray cartridge having the nozzle with a 45degree exit angle according to an embodiment of the invention.

FIG. 5B shows a side view of an exemplary dermal spray deviceincorporating the nozzle of FIG. 5A where the cartridge is closed withinthe device.

FIG. 5C shows a close up view of the nozzle body of the dermal spraycartridge of FIG. 5A.

FIG. 5D shows a cross-sectional view of the dermal spray device of FIG.5A.

FIG. 6A shows a schematic view of a dermal spray device according to anaspect of the invention.

FIG. 6B shows a perspective view of the dermal spray device shownschematically in FIG. 6A.

FIG. 7A shows a schematic view of a dermal spray device according to anaspect of the invention.

FIG. 7B shows a perspective view of the dermal spray device shownschematically in FIG. 7A.

FIG. 8A shows a schematic view of a dermal spray device according to anaspect of the invention.

FIG. 8B shows a perspective view of the dermal spray device shownschematically in FIG. 8A.

FIG. 9A shows a schematic view of a dermal spray device according to anaspect of the invention.

FIG. 9B shows a perspective view of the dermal spray device shownschematically in FIG. 9A.

FIG. 10A shows a schematic view of a dermal spray device according to anaspect of the invention.

FIG. 10B shows a perspective view of the dermal spray device shownschematically in FIG. 10A.

DETAILED DESCRIPTION OF THE INVENTION

The present invention involves improvements to dermal spray systems thatprovide unique advantages for dermal and topical application.

FIG. 1 shows a dermal spray device 32 described in U.S. patentapplication Ser. No. 17/224,824, entitled “DERMAL SPRAY DEVICE ANDMETHOD”, filed Apr. 7, 2021. Hidden lines are used to reveal theinternal components of the device 32. The device includes a spray head36, including a nozzle 38, and a body 34. The body 34 includes apressure source 52 such as an air compressor that can be used to propela dermal composition supplied in a container 60 when the user presses abutton 40 mounted on the body 34.

The device 32 includes a battery 50, control circuitry 54, a datastorage unit 76, a data transmission unit 77 that is configured topermit data transmission of device data 79 to and from a mobile device78, such as a smartphone. The mobile device 78 can communicate with aserver 81 using a secure internet connection 82, to communicate userdevice data between the server and mobile device. The mobile device 78is configured (a) to combine the device data with secure user data intouser device data, and (b) to display the user device data to the user.The mobile device may send anonymized user device data to the server,which can be used to build a database that can be utilized in severalmachine learning processes of aid in the selection of serums. The devicealso includes an accelerometer 80 and an encoding identification unit86.

The capsule 60 is inserted into a compartment 46 the dermal spray device32. The compartment 60 includes a door 44 and a capsule nest 58 forholding the capsule in place. A needle 62 penetrates the capsule 60 andallows the contents of the capsule to be drawn toward the nozzle 38. Airfrom a pressure chamber 64 is routed to the nozzle through a pressurizedconduit 56. Further details regarding the dermal spray device and itsuse may be found in U.S. patent application Ser. No. 17/224,824,incorporated above. The inventors have perceived a need to improve thespray device 32 in several respects.

The present inventors have perceived a need to provide a cartridgesystem for a dermal spray device that has one or more of the followingfeatures. In one aspect, the cartridge is capable of being stored andeasily pierced at the time of use. In another aspect, the cartridge maybe easily inserted into a spray device and activated after it ispositioned within the spray device. In another aspect, the cartridge hasa disposable nozzle that eliminates or reduces the need for cleaning ofthe dermal spray device. In another aspect, the cartridge is capable ofbeing filled and dispensed without air pockets interfering with theconsistent dispensing of contents.

A cartridge is provided for dispensing a liquid from a dermal spraydevice, wherein the cartridges includes a nozzle assembly, a fluidreservoir, and a cap attached to the fluid reservoir that is adapted toengage the nozzle assembly. The cartridge includes a disposable nozzleassembly that is attached to the cartridge. When the cartridge isinserted into the device the nozzle assembly is moved into a positionthat allows an inner body, e.g., a needle, to pierce a reservoir andallow liquid to enter the nozzle assembly.

A cartridge 200 according to one aspect of the invention is shown inFIGS. 2A-G. The cartridge 200 includes a reservoir body 202, a reservoircap 201 and to which a nozzle assembly is attached. The nozzle assemblyincludes an outer nozzle body 208 and an inner nozzle body 220. Theinner nozzle body 220 is rigidly attached to the outer nozzle body 208.The inner nozzle body 220 preferably has a tapered outer surface 221,and the outer nozzle body 208 has a tapered inner surface 225. The spacebetween the outer surface 221 of the inner nozzle body 220 and the innersurface 225 of the outer nozzle body 208 form a fluid passage of thenozzle assembly for delivering compressed air. Compressed air isprovided into the passage through a fluid attachment point 224. Theinner nozzle body 220 has a first end 226 and a second end 223, thesecond end being adapted to pierce a seal in the reservoir body 202 andprovide liquid material from the reservoir body (e.g., aliquid-containing pouch) to the spray nozzle.

FIGS. 2B-E show aspects of the reservoir body 202 of the cartridge 200.This includes a reservoir cap 201 and flat edges 205. Also provided isguide post 203 adapted to receive the nozzle assembly shown in FIG. 2A.The reservoir cap 201 includes a reservoir cap recess 207 as shown inFIG. 2F. As shown in FIGS. 2C and 2E, the guide post 203 includes aguide slot 204 that is adapted to define a controlled sliding movementof the inner nozzle body 220 through the opening 206 relative to thereservoir body 202. This movement is used to allow the second end 223 ofthe inner nozzle 220 to pierce the reservoir body 202. If desired, theguide slot may include curvature so that the nozzle assembly rotates byfor example 90 degrees while it is being engaged.

FIG. 2F shows the details of the nozzle assembly when it is slid intothe engaged position relative to reservoir body. The fluid attachmentpoint 224 includes a passage 227 linking it to the recess between theouter nozzle body 208 and the inner nozzle body 220. Portions of theguide post 203 are shown projecting above the guide flanges 222. Theinner nozzle body 220 and outer nozzle body 208 can be made by injectionmolding of rigid plastic materials. It is important for the materials tobe strong enough to maintain precise tolerances of the fluid passage,and allow for movement of the inner nozzle body 220 and outer nozzlebody 208 relative to the fluid reservoir 201.

FIG. 2G shows a perspective view of the nozzle assembly. It should benoted that the guide flanges 222 may be seated in the outer nozzle body208 by insertion into the nozzle body recesses 228. The seal 229 isshown in the reservoir cap 201 in FIG. 2G. The seal 229 may be made of amaterial that can be readily pierced by the second end 223 of the innernozzle body 220. While the flange 222 and guide slot 204 are pictured ina form that is adapted for back and forth motion of the nozzle assembly,other configurations are possible. For example the guide flange may beprovided in cylindrical form and the notch designed to permit both backand forth movement as well as twisting movement. In one instance, thenozzle assembly may be configured to rotate by a desired amount such as45 degrees or 90 degrees such that the inner nozzle body pierces theseal 229 at the end of the motion, allowing the liquid contents of thefluid reservoir to move into the fluid passage within the inner nozzlebody.

In one aspect, fluid reservoirs may be manufactured using a process asshown in FIG. 3 . A bottom film 320 and top film 321 are fed fromrespective feeding spindles 310 through a series of rollers 312 into amold for heat welding 313. The mold 313 may include a lower moldfoundation 314 and an actuator 311 which opens and closes the mold. Acutter including a bottom cutting element 315 and top cutting element316 can be intermittently engaged to cut away finished pouches 322 ofeach fluid reservoir. While this method is advantageous for the rapidproduction of a larger number of reservoirs other techniques may be usedto manufacture a fluid reservoir. In addition, it is possible to usedifferent types or reservoirs with the cartridges of the presentinvention.

In one aspect, one or both of the bottom film 320 and top film 321 usedto make the reservoir is a flexible plastic film that allows thereservoir to collapse as fluid is withdrawn from the reservoir. Forexample, the film may be a polyethylene terephthalate (PET) film havinga thickness of between 40-50 microns. In one aspect, the film mayinclude two or more layers of film that are adhered together. In thiscase, a radio frequency identification (RFID) tag or other informationcontaining device may be positioned between separate layers of amultilayer film that makes up the reservoir. The RFID tag may includeinformation about the dermal serum or material contained within thecartridge that may be read by the dermal spray device upon insertion ofthe cartridge into the device. In another aspect, the cartridge maycontain a barcode, NFC, QR code or other information containingmechanism that is read by the dermal spray device.

FIGS. 4A-F show a cartridge and system according to another aspect ofthe invention, wherein the nozzle assembly has a 45 degree bend. Theangle of the bend may range from 0 degrees to 90 degrees, and can dependon the geometry of the dermal spray device. The cartridge 400 includes areservoir cap 401, reservoir body 402, and nozzle body 408. Thereservoir cap 401 has a guide post 403 that includes guide slots 404 oneither side to allow for up and down movement of the nozzle assemblyrelative to the reservoir body 402. The reservoir body may have flatedges 405 around its periphery.

The nozzle assembly includes an inner nozzle body 420 having a taperedouter surface 421 and a guide flange 422. The inner nozzle body 420 hasa first end 426 and a second end 423. The outer nozzle body 408 includesa tapered inner surface 425 and the inner nozzle body 420 has a taperedouter surface 421. These surfaces form an air passage to the nozzlethrough fluid passage 430. Fluid moves from the reservoir through thefluid passage 427 through the inner nozzle body 420. The fluid passageincludes a bend 431. The bend 431 is shown having an angle but may alsobe smooth. FIG. 4B shows a cartridge including the nozzle shown in FIG.4A. The cartridge includes a nozzle body 408, which is attached to afluid reservoir 402 having flat sides 405 by way of a guide post 403with guide slot 404 being provided on a reservoir cap 401.

FIG. 4C-F shows how a the nozzle body 408 assembled on a dermal spraydevice. The dermal spray device has a handle body 440 and a handle base442. The device includes a door 443 for insertion of a cartridge. Thespray device includes a recess 446 that provides clearance of the nozzlebody 408 when the cartridge is inserted into the spray device. The spraydevice may include a button 444 for activating the sprayer.

FIG. 5A shows a cartridge having a nozzle body 508 that includes anozzle outlet 526 that has a 45 degree angle 5 relative to the fluidreservoir 502. The fluid reservoir may include a flat edge 505 asdescribed above. The nozzle body 508 includes a sloped guide 591 on bothsides of the nozzle body. When the device cap 543 is slid laterally intoposition as shown in FIG. 5B, a cam or wing (not shown) on the undersideof the device cap 543 engages with the sloped guide 591 and exerts adownward pressure on the outer nozzle body 508 and nozzle assembly. Thedownward force of the nozzle assembly allows the second end of the innernozzle body to pierce the seal of the reservoir body 502 allowing theliquid from the reservoir body to be drawn into the fluid passage withinthe inner nozzle body. The nozzle body may include a guide post 503 thatincludes guide flanges 504 on either side to allow for up and downmovement of the nozzle assembly.

The cartridge including the reservoir 502 and nozzle body 508 isinserted into a slot 562 in the handle body 540 of the dermal spraydevice. A button 544 is provided for activating the device. A connection590 allows pressurized gas (e.g., compressed air) to flow into a fluidpassage in the bottom of the nozzle body 508 that is directed to thetapered gap between the inner nozzle body and outer nozzle body. Thefluid is typically pressurized air that mixes with fluid from the fluidreservoir 502 at or near the nozzle outlet 526.

FIG. 5D shows a cross section view that includes many of the elementsdiscussed above. In addition to those elements, a battery 561 is shownin the handle assembly, and an induction coil 566 is shown near the baseof the handle body. The induction coil cooperates with electric powertransmitted through the base 542 to conveniently charge the device. Anair compressor 564 is provided to supply compressed air to the nozzlebody 508 through conduit 571. A PCB 563 is provided within the handle toprovide control and other functionality to the dermal spray device.

FIG. 6A-B show a dermal spray device where a cartridge is inserted andpositioned into place by a vertically sliding door 643. The deviceincludes a nozzle body 608 connected to a reservoir 601, a compressor664 and a fluid conduit 671 connecting the compressor 664 to the nozzlebody 608. The device includes a button 644 for activating the spray, aprinted circuit board 663 and a battery 661. A perspective view of thedermal spray device is shown in FIG. 6B showing the motion of the door643 that encloses the cartridge within the handle body 640 of the dermalspray device.

FIG. 7A-B show another dermal spray device where a cartridge is insertedand positioned into place by a vertically sliding door 743. The deviceincludes a nozzle body 708 connected to a reservoir 701, a compressor764 and a fluid conduit 771 connecting the compressor 764 to the nozzlebody 708. The device includes a printed circuit board 763 and a battery761. A perspective view of the dermal spray device is shown in FIG. 7Bshowing the motion of the door 743 that encloses the cartridge withinthe handle body 740 of the dermal spray device.

FIG. 8A-B show a dermal spray device where a cartridge is inserted andpositioned by pushing up into a receiver and then enclosed with acartridge tray 862. The device includes a nozzle body 808 connected to areservoir 801, and a compressor 864. The device includes a printedcircuit board 863 and a battery 861. A side view of the dermal spraydevice is shown in FIG. 8B showing the motion of the cartridge tray 862that encloses the cartridge within the handle body 840 of the dermalspray device.

FIG. 9A-B show a dermal spray device where a cartridge is inserted andpositioned laterally into the device and closed by a door 943. Thedevice includes a nozzle body 908 connected to a reservoir 901, acompressor 964 and a fluid conduit 971 connecting the compressor 964 tothe nozzle body 908. The device includes a printed circuit board 963 anda battery 961. A perspective view of the dermal spray device is shown inFIG. 9B showing the motion of the door 943 that encloses the cartridgewithin the handle body 940 of the dermal spray device. The door 943includes an spray opening 979 that allows spray from the nozzle to passthrough.

FIG. 10A-B show a dermal spray device where a cartridge is inserted andpositioned laterally into the device and closed by a vertically slidingdoor 1043. The device includes a nozzle body 1008 connected to areservoir 1001, a compressor 1064 and a fluid conduit connecting thecompressor 1064 to the nozzle body 1008. The device includes a printedcircuit board 1063 and a battery 1061. A side view of the dermal spraydevice is shown in FIG. 10B showing the motion of the door 1043 thatencloses the cartridge within the handle body 1040 of the dermal spraydevice. The door 1043 includes an spray opening 1079 that allows sprayfrom the nozzle to pass through.

Other embodiments and uses of the invention will be apparent to thoseskilled in the art from consideration of the specification and practiceof the invention disclosed herein. All references cited herein,including all U.S. and foreign patents and patent applications, arespecifically and entirely hereby incorporated herein by reference. It isintended that the specification and examples be considered exemplaryonly, with the true scope and spirit of the invention indicated by thefollowing claims.

1-19. (canceled)
 20. A dermal spray system for dispensing liquid from a cartridge, the dermal spray device comprising: a handle body; a source of a compressed air; a device cap; a cartridge assembly; and a cartridge receiver, wherein the cartridge receiver is part of the handle body and is adapted to accept the cartridge assembly including a liquid reservoir, a reservoir cap, and a nozzle assembly, and the device cap is adapted to engage with the cartridge assembly to move the nozzle assembly in a controlled direction relative to the reservoir cap and pierce the liquid reservoir; wherein the dermal spray device dispenses liquid from the cartridge by supplying the compressed air to the nozzle of the cartridge, the nozzle drawing liquid from the liquid container and mixing it with the compressed air; and wherein the cartridge assembly comprises: the nozzle assembly, the liquid reservoir, and the reservoir cap attached to the liquid reservoir, wherein the reservoir cap is adapted to engage the nozzle assembly; the nozzle assembly comprising an inner body and an outer body, the inner body and outer body forming a first fluid passage therebetween, the first fluid passage adapted to deliver compressed air, the inner body comprising a second fluid passage in its interior, the second fluid passage adapted to deliver liquid from the liquid reservoir; wherein the nozzle assembly is moveable in a controlled direction relative to the reservoir cap; and the inner body of the nozzle assembly is adapted to pierce the liquid reservoir when the nozzle assembly is moved in the direction of the liquid reservoir to allow liquid from the liquid reservoir to flow into the second fluid passage.
 21. The dermal spray system of claim 20, wherein the nozzle assembly comprises a guide adapted to translate lateral motion into vertical motion for engaging the nozzle assembly with the liquid reservoir.
 22. The dermal spray system of claim 20, wherein the liquid reservoir comprises a pouch and the reservoir cap seals the pouch.
 23. The dermal spray system of claim 20, wherein the reservoir cap includes recesses for capturing air bubbles in the liquid of the reservoir.
 24. The dermal spray system of claim 20, wherein the nozzle assembly further comprise at least one guide flange adapted to guide movement of the nozzle assembly in a back and forth direction relative to the liquid reservoir.
 25. The dermal spray system of claim 24, wherein the guide flange is designed to guide movement of the nozzle assembly in a rotational direction relative to the liquid reservoir in addition to a back and forth direction relative to the liquid reservoir.
 26. The dermal spray system of claim 20, wherein the outer nozzle body has a conical shape.
 27. The dermal spray system of claim 20, wherein the outer nozzle body has a rectangular shape.
 28. The dermal spray system of claim 20, wherein the outer nozzle body has a rectangular shape and the first fluid path and second fluid path exit the nozzle body at about a 45 degree angle relative to the horizontal.
 29. The dermal spray system of claim 20, wherein the outer nozzle body comprises a first guide member and a second guide member, wherein the first guide member and second guide member are adapted to engage with the device cap in a manner that permits the nozzle assembly to move in a controlled direction relative to the reservoir cap.
 30. The dermal spray system of claim 20, wherein the device cap is a sliding device cap adapted to position the cartridge in the dermal spray device wherein the cartridge so positioned is capable of dispensing liquid through the spray nozzle.
 31. The dermal spray system of claim 30, wherein the device cap is adapted to engage with spray nozzle of the cartridge and activate the spray nozzle when the device cap is moved into an engaged position.
 32. The dermal spray system of claim 20, further comprising a base with an inductive charging element that allows for charging of a battery of the dermal spray system.
 33. The dermal spray system of claim 20, wherein the cartridge is disposable. 